Chromosome Biology and Mitotic Signaling

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1. Variable and hierarchical size distribution of L1-retroelement-enriched CENP-A clusters within a functional human neocentromere. Chueh AC, Wong LH, Wong N, Choo KHA. Human Molecular Genetics. 2005 Jan 1;14(1):85-93. IF = 7.636 (57)

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2. LINE retrotransposon RNA is an essential structural and functional epigenetic component of a core neocentromeric chromatin. Chueh AC, Northrop EL, Brettingham-Moore KH, Choo KH, Wong LH. PLoS Genetics. 2009 Jan;5(1):e1000354. IF = 8.694 (100)

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3. BAC-based PCR fragment microarray: high-resolution detection of chromosomal deletion and duplication breakpoints. Ren H, Francis W, Boys A, Chueh AC, Wong N, La P, Wong LH, Ryan J, Slater HR, Choo KHA. Human Mutation. 2005 May;25(5):476-82. IF = 5.686 (34)

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Epigenetic Regulation and Biomarkers

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4. ATF3 repression of BCL-XL determines apoptotic sensitivity to HDAC inhibitors across tumour types. Chueh AC, Tse JW, Dickinson M, Ioannidis P, Jenkins L, Tögel L, Tan BS, Dávalos-Salas M, Nightingale R, Thompson MR, Williams BR, Lessene G, Lee E, Fairlie WD, Dhillon AS, Mariadason JM. Clinical Cancer Research. Manuscript accepted. IF = 8.738 (0)

 

5. Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. Wilson AJ, Chueh AC, Tögel L, Corner GA, Ahmed N, Goel S, Byun DS, Nasser S, Houston MA, Jhawer M, Smartt HJ, Murray LB, Nicholas C, Heerdt BG, Arango D, Augenlicht LH, Mariadason JM.

Cancer Research. 2010 Jan 15;70(2):609-20. IF = 7.856 (69)

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6. Promoter hypomethylation of NY-ESO-1, association with clinicopathologicalfeatures and PD-L1 expression in non-small cell lung cancer. Chueh AC, Liew MS, Russell A , Walkiewicz M, Jayachandran A, Starmans MHW, Boutros PC, Wright G, Barnett SA, Mariadason JM, John T. Oncotarget. Manuscript accepted. IF = 5.008 (0)

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7. Combinatorial targeting of the bromodomain and extra terminal domain (BET) family, and the Wnt and MAPK pathways, inhibits c-MYC expression and proliferation of colorectal cancer cells. Tögel L, Nightingale R, Chueh AC, Jayachardran A, Tran H, Phesse T, Wu R, Sieber OM, Arango D, Arango D, Dhillon AS, Dawson MA, Beatriz D, Gahman TC, Filippakopoulos P, Shiau AK, Mariadason JM. Molecular Cancer Therapeutics. 2016 Jun;15(6):1217-26. IF = 5.683 (9)

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8. Epigenetic silencing of the negative feedback regulator of mitogen-activated protein kinase (MAPK) signalling, DUSP5, in colorectal cancer. Togel L, Arango D, Chueh AC, Sieber OM, Mariadason JM. European Journal of Cancer. 48, S155-S155 (2012). IF = 5.536 (0)

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9. The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner Shin J, Carr A, Corner GA, Tögel L, Dávalos-Salas M, Tran H, Chueh AC, Al-Obaidi S, Chionh F, Ahmed N, Buchanan DD, Young JP, Malo MS, Hodin RA, Arango D, Sieber OM, Augenlicht LH, Dhillon AS, Weber TK, Mariadason JM. Journal of Biological Chemistry. 2015 Jun 19;290(25):15392. IF=4.773 (2)

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10. Transketolase-like 1 ectopic expression is associated with 1 DNA hypomethylation and induces the Warburg effect in melanoma cells. Jayachandran A, Lo PH, Chueh AC, Prithviraj P, Molania R, Dávalos-Salas M, Anaka M, Walkiewicz M, Cebon J, Behren A

BMC Cancer, 2016 Feb 22. IF=3.011 (6)

 

Cancer Biology and Therapeutic Targets

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11. Molecular imaging of death receptor 5 occupancy and saturation kinetics in vivo by humanized monoclonal antibody CS-1008. Burvenich IJ, Lee FT, Cartwright GA, O'Keefe GJ, Makris D, Cao D, Gong S, Chueh AC, Mariadason JM, Brechbiel MW, Beckman RA, Fujiwara K, von Roemeling R, Scott AM. Clinical Cancer Research. 2013 Nov 1;19(21):5984-93. IF = 7.742 (11)

 

12. PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity. Gilan O, Diesch J, Amalia M, Jastrzebski K, Chueh AC, Verrills NM, Pearson RB, Mariadason JM, Tulchinsky E, Hannan RD, Dhillon AS. Oncogene. 2015 Mar 5;34(10):1333-1339. IF = 6.373 (6)

 

13. FoxP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis. Tan B, Anaka M, Deb S, Freyer C, Ebert LM, Chueh AC, Al-Obaidi S, Behren A, Jayachandran A, Cebon J, Chen W*, Mariadason JM*. Oncotarget. 2014 Jan 15;5(1):264-76. IF= 6.636 (18) *These authors contributed equally to this work

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